Find diseases associated with this biological target and compounds tested against it in bioassay experiments. The presence of both gpatch and kow domains in the mos2 protein suggests that it probably functions as an rna binding protein critical for. It also has 2 putative pka see 188830 phosphorylation sites. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under quick quote. Human gpkow g patch glycinerich domain and kow kyrpides, ouzounis and woese domain protein contains a g patch domain and two kow domains, and is a homologue of arabidopsis mos2 and saccharomyces spp2 protein.
Gpkow is a nuclear protein with three nucleic acid binding domains, one gpatch domain and two kowmotifs. We are committed to sharing findings related to covid19 as quickly and safely as possible. Tell a friend about us, add a link to this page, or visit the webmasters page for free fun content. This gene encodes a protein with g patch and kow domains which are involved in rna binding. Loc112453279 gpatch domain and kow motifscontaining protein gene id. G patch domain and kow motifscontaining protein, gpkow. Gpkow is a putative rnabinding protein containing g patch and kow kyprides, ouzounis, woese domains.
Elabscience is a famous biology science research reagents manufacturer. Using yeast twohybrid screening with the pka c subunit cbeta2 as bait, we identified the gpatch domain and kow motifscontaining protein gpkow, also known as the t54 protein or mos2 homolog. Based on this we speculate if the specificity of the c subunit in regulating premrna splicing may be mediated indirectly through other nuclear proteins. We demonstrate that gpkow, which contains one g patch domain and two kow motifs, is a nuclear rnabinding protein conserved between species. Ipr041993 g patch domain and kow motifscontaining protein, kow 1. G patch domains and kow motifs are predicted to bind proteins andor singlestranded nucleic acids. G patch domain containing protein 8 is a protein that in humans is encoded by the gpatch8 gene hyperuricemia. Research article open access gpatch domain and kow. Gpkow, gpatch domain and kow motifs, t54, gpatch5, gpatc5, spp2, xp11. Using yeast twohybrid screening with the pka c subunit cbeta2 as bait, we identified the gpatch domain and kow motifscontaining protein gpkow, also known as the t54 protein or mos2 homolog, as an interaction partner for cbeta2. Ipr041994 g patch domain and kow motifscontaining protein, kow 2. Compare anti g patch domain and kow motifs antibody products from leading suppliers on biocompare.
Immunogen g patch domain and kow motifscontaining protein recombinant protein epitope signature tag prest application antigpkow antibody has been used in western blotting. Gpatch domain and kow motifscontaining protein, gpkow ncbi. Protein target information for g patch domain and kow motifs cattle. Check more details about gpkow polyclonal antibody now. Ipr041993 gpatch domain and kow motifscontaining protein, kow 1. Read mos2, a protein containing g patch and kow motifs, is essential for innate immunity in arabidopsis thaliana, current biology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Gpkow is found in the human spliceosome, but its role in premrna splicing remains to be elucidated. High affinity and specificity gpkow polyclonal antibody at. Using yeast twohybrid screening with the pka c subunit cbeta2 as bait, we identified the gpatch domain and kow motifscontaining protein. The g patch is a glycinerich domain discovered by sequence alignment, involved in protein protein and protein nucleic acid interaction. Orthologs of kiaa0553 were detected in several vertebrate species, with highest conservation in the cterminal domain. Feature key positions description actions graphical view length. Gpkow is a potential rnabinding protein consisting of one central g patch domain and two cterminal kow domains. Gpkow is essential for premrna splicing in vitro and.
Signatures from interpro member databases are used to construct an entry. Antigpatch domain and kow motifs antibody products. By anne kristin aksaas, anja cv larsen, marie rogne, ken rosendal. The bar plot below shows the proportion of tumor samples that have any kind of altering mutations in the given protein. We have demonstrated that gpkow binds rna in vivo and that gpkow associate with c. Rnabinding proteins and posttranscriptional gene regulation. The deduced protein contains a central g patch domain, followed by 2 kow motifs. Looking for online definition of g patch domain and kow motifscontaining protein in the medical dictionary. Using yeast twohybrid screening with the pka c subunit cbeta2 as bait, we identified the g patch domain and kow motifscontaining protein gpkow, also known as the t54 protein or. Gpkow gpatch domain and kow motifscontaining protein. Gpkow mgi mouse gene detail g patch domain and kow motifs. Gpkow interacts directly with protein kinase a and protein kinase x and is also found associated with the spliceosome. G patch domain and kow motifscontaining protein add blast. Gpatch domain and kow motifscontaining protein, gpkow.
Rna helicases from the deahrha family are present in all the processes of rna metabolism. We will be providing unlimited waivers of publication charges for accepted articles related to covid19. Mos2, which contains one g patch domain and two kow motifs organized in the same way as gpkow, is involved in innate immunity via the disease resistance genes in plants. Hyperuricemia cosegregating with osteogenesis imperfecta has been shown to be associated with a mutation in gpatch8 using exome sequencing.
Mos2, a protein containing gpatch and kow motifs, is. We demonstrate that gpkow, which contains one gpatch domain and two kow motifs, is a nuclear rnabinding protein conserved between species. Rbm10, rna binding motif protein 10, s11, dxs8237e, kiaa0122, zranb5, gpatch9, gpatc9. Gpatch domain containing gpatch gene family hugo gene. Gpkow interacts directly with protein kinase a and protein kinase x and is also found associated with the spliceosom taken from ncbi entrez gene gene id. Meaning of g patch domain and kow motifscontaining protein medical term. The latter assumption is also indicated by the importance of g patch proteins in carcinogenesis 66,67. Protein annotations for g patch domaincontaining protein. Ipr008991 translation protein sh3like domain superfamily. G protein coupled receptor 142 gramd1a gram domain containing 1a helb helicase dna b hist1h2ae. The function of two helicases from this family, prp2 and prp43, is regulated by protein partners containing a g patch domain. Gpkow is a a putative rnabinding protein containing g patch and kow kyprides, ouzounis, woese domains. Protein analysis mass spectrometry protein expression protein interactions protein purification. What is g patch domain and kow motifscontaining protein.
Gpkow protein consists of one g patch domain and two kow motifs. It is a mammalian homolog of the arabidopsis thaliana mos2 modifier of snc1, 2 nuclear protein that is required for innate immunity. Proteins listed in protbank database are not offtheshelf catalog proteins. Gpkow contains two sites that are phosphorylated by pka in vitro. G patch domain and kow motifscontaining protein explanation free. Loc109036472 g patch domain and kow motifscontaining protein gene id. G patch domain and kow motifs definition of g patch. Gpkows ability to bind rna is regulated by pkadependent phosphorylation at two sites. Mos2, a protein containing gpatch and kow motifs, is essential.
Gpkow contains two sites that are phosphorylated by pka. This gene encodes a putative rnabinding protein containing g patch and kow kyprides, ouzounis, woese domains. Spp2mos2, gpatch domain ipr026822 proteins containing this g patch domain also include the plant mos2 protein, which is required for innate and induced resistance to pathogens, and mos2 homologues from metazoa pmid. Gpatch domain and kow motifs cattle protein target. Antig patch domain and kow motifscontaining protein antibody produced in rabbit, antig patch domaincontaining protein 5 antibody produced in. Table 1 molecular integrity of mitochondria alters by. The presence of both g patch and kow domains in the mos2 protein suggests that it probably functions as an rna binding protein critical for plant innate immunity 4, 5. Using yeast twohybrid screening with the pka c subunit cbeta2 as bait, we identified the g patch domain and kow motifscontaining protein gpkow, also known as the t54 protein or mos2 homolog, as an interaction partner for cbeta2. Pdf gpatch domain and kow motifscontaining protein. T54 is a 476 amino acid protein belonging to the mos2 family.
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