The microemulsion region is presented in the diagram and rest of the region represents formation of emulsion or gel. Its observe solubility in oil, surfactant and cosurfactant and having diameter in the range of 100a 10100 nm. The microemulsion region computed was comparable to the findings of chen et al. A recent approach for topical drug delivery system article pdf available in research journal of pharmacy and technology 82. Microemulsion based bioadhesive gel of itraconazole using. Formulation and characterization of microemulsion based gel. Evaluation of microemulsion based hydrogel globule size determination the average droplet size of samples was measured at 25c by malvern zeta sizer. Hence, the formulation of cxb was selected for sol to find out suitable formulation for microemulsion, the solubility of cxb in triacetin oil phase, tween 80 surfactant, and transcutolp cosurfactant was screened respectively and optimized.
The oilinwater microemulsion is first prepared and evaluated and then incorporated into a gel base and this dosage form is referred to a microemulsion based gel. Pharmaceutical compositions derived from microemulsion based gels. The prepared nanoemulsions were subjected to different thermodynamic stability tests. To overcome the above drawback, the low viscous microemulsions were added to viscous gel bases to potentiate its applications as topical drug delivery systems so that various drug related toxic effects and erratic drug absorption can be avoided. Optimization of microemulsion based transdermal gel of. Microemulsion was evaluated for globule size fesem, zetasizer, % transmittance, ph, viscosity, conductivity etc. They offer numerous advantages like improved solubilization of both hydrophilic and lipophilic drugs, better bioavailability, prolong and targeted release, enhanced permeation across biological membranes, protection against oxidation, better stability and ease of manufacturing as well as. Microemulsion based novel transdermal delivery system of tetramethylpyrazine. The optimized microemulgel f1 showed acceptable physical properties with lowest viscosity value 2325 cps and showed pseudoplastic behaviour, highest spreadability value 3. When gel and microemulsion are used in combined form and the dosage forms are referred as microemulsion based gel. Design and study of poloxamerbased microemulsion gels with. Pdf formulation and characterization of clotrimazole.
Jul 02, 2011 stability study on the selected ctm microemulsion liquid and gel. Novel isotretinoin microemulsionbased gel for targeted. Luliconazole emulsion equivalent to 1g was added to gel matrix of sodium alginate using magnetic stirrer to remove any formation. The aim of the present study was to design nanocarriers for the topical application of rivastigmine. The solubility of cmz in oils and surfactants was evaluated to identify components of the microemulsion.
Phospholipid microemulsionbased hydrogel for enhanced. The buffer in the reservoir compartment was stirred continuously at a constant speed. To deliver 2,3,5,6tetramethylpyrazine tmp in a relatively. Formulation and evaluation of microemulsion based topical. Lower irritation microemulsionbased rotigotine gel.
Hence, the developed phospholipid microemulsion based gel formulation has been proposed as more useful alternative for the topical delivery of lidocaine and prilocaine. Novel gellike microemulsion for topical delivery of amphotericin b. The bioadhesive potential and antifungal activity of the cmz microemulsion based gel cmzmbg was determined in comparison to the marketed clotrimazole gel candidv gel by in vitro methods. Microemulsion in enhanced oil recovery, detergency, cosmetics, agrochemicals, food. The developed gel showed promising in vitro performance with respect to bioadhesivity and antifungal activity. Carbopol 971p and hpmc k100m were used as independent variables. Pdf microemulsionbased vaginal gel of clotrimazole.
Lecithinlinker microemulsion based gels for drug delivery xiao yue xuan master of applied science department of chemical engineering and applied chemistry university of toronto 2011 abstract microemulsions have gained interest from the pharmaceutical industry due to their ability to co. The traditional experimentation based on trial and. The aim of the present study was to investigate the potential of a nanoemulsion formulation for topical delivery of aceclofenac. Gupta faculty of pharmacy, dehradun institute of technology, dehradun, uttarakhand, india are cited, but the list is by no means exhaustive. Microemulsion is a nanoparticle synthesis technique in which two immiscible fluids such as water in oil wo, oil in water ow or water in supercritical carbon dioxide wsc co2 are thermodynamically stabilized with the aid of a surfactant. Novel isotretinoin microemulsionbased gel for targeted topical therapy of acne. Pdf microemulsion based bioadhesive gel of itraconazole.
The microemulsion is stabilized by means of the surfactant. Microemulsion based gel was evaluated for invitro as well as exvivo parameters. Design, development, and optimization of dexibuprofen. Various oilinwater nanoemulsions were prepared by the spontaneous emulsification method. Formulation, characterization, and clinical evaluation of. Nanoemulsion and nanoemulgel as a topical formulation. Microemulsion based gel of voriconazole broadspectrum antifungal agent could be an effective strategy for treatment of topical fungal infections.
The nanoemulsion area was identified by constructing pseudoternary phase diagrams. Aug 24, 2017 clotrimazole microemulsion and microemulsion. To develop microemulsion based hydrogel of voriconazole was for effective treatment of skin mycosis. Microemulsions can improve skin penetration of lycopene. Apr 10, 2017 the aim of the current research was to investigate the release of diclofenac sodium, a poorly watersoluble drug from different formulations in vitro. Phospholipid microemulsionbased hydrogel for enhanced topical delivery of lidocaine and prilocaine. A microemulsion me was prepared using caprylocaproyl polyoxyl8 glycerides, diethylene glycol monoethyl ether, and propylene glycol monolaurate. Microemulsionbased novel transdermal delivery system of. Development and evaluation of microemulsion based gel mbgs containing econazole nitrate for nail fungal infection. Formulation and evaluation of microemulsion based gel of. Formulation development, in vitro and in vivo evaluation of. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. The irritancy of formulation was determined based on the method described by draize et al.
Psu center of excellence on drug delivery system, prince of songkla university. They offer numerous advantages like improved solubilization of both hydrophilic and lipophilic drugs, better bioavailability, prolong and targeted release, enhanced permeation across biological membranes, protection against. Microemulsion formation is spontaneous and does not require much energy. In this study novel microemulsion based gels with poloxamer 182 as a surfactant were designed and investigated as potential carriers for topical dosage forms with naproxen, nonsteroidal antiinflammatory drug. Evaluation of a microemulsionbased gel formulation for topical drug. Formulation and characterization of microemulsion based. However, cmz showed a considerable degradation on longterm storage in the developed microemulsion based gel which was attributed to. University institute of pharmaceutical sciences, panjab university, chandigarh 160 014, university institute of pharmaceutical sciences, panjab university, chandigarh 160 014, department.
Microemulsion as a vehicle for transdermal permeation of nimesulide. Original article formulation and evaluation of microemulsion. Keywords analgesic, eutectic mixture, local anesthetic, phospholipids, skinpermeation history received 17 april 2014 revised 7 may 2014 accepted 7 may 2014 introduction. Thermoresponsive nanoemulsionbased gel synthesized. Formulation and evaluation of microemulsion based gel of oriconazole for topical delivery volume. Formulation, development and evaluation of etoricoxib. Microemulsion based gels have emerged as one of the most intresting topical drug delivery system as it has dual control release system i. Pdf development and evaluation of microemulsion based. The objective of the present investigation was to develop and evaluate microemulsion based gel for the vaginal delivery of clotrimazole cmz. Patil department of pharmaceutics, mets institute of pharmacy, bhujbal knowledge city, adgaon, nashik, india abstract background.
Evaluation of a microemulsionbased gel formulation for. The microemulsion based gel could be successfully developed for the vaginal delivery of clotrimazole. Aliquots were withdrawn and were suitably diluted, filtered if needed and then injected into hplc perkin elmer for analysis of drug content. Oil and water are immiscible and they separate into two phases when mixed, each saturated with traces of the other component capek, 1999. Approximately two third of population throughout the world is affected by a common fungal infection1. Gellike microemulsion, amphotericin b, topical delivery, cutaneous leishmaniasis. The aim of present work was to formulate and evaluate microemulsion based topical sulconazole gel. Thermoresponsive nanoemulsionbased gel synthesized through a. These higher viscosity systems are more suitable for topical administration. Also the small size of the drug droplets in microemulsion yields large interfacial area, from which the drug can. The term microemulsion refers to a thermodynamically stable, isotropic clear. Pdf development and evaluation of microemulsion based gel.
Two microemulsion were selected based on the globule area, pdi and physical stability and incorporated into the gel base of sodium alginate. Formulation and characterization of microemulsion based gel of. Gelbased microemulsion design and evaluation for topical. It is characteristic that a gelatinizer and water are added to the microemulsion thereby bringing the microemulsion into a gel form. Us6004580a pharmaceutical compositions derived from. Moreover, microemulsion based gel limits the absorption of drug in systemic circulation and provides higher drug accumulation in the skin for efficient action 10. For enhancing the viscosity, carbopol was used to form an me based gel. Nimesulide has extensively used for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old and in the treatment of rheumatoid arthritis and inflammatory conditions. So based on the stability, e1 and e4 were selected as optimized emulsion. The results indicated that cxb microemulsionbased gel had better bioavailability than celebrex. Lavjot kaur, rakesh kumar, deepak kumar rahi and vivek ranjan sinha affiliation.
Microemulsion based bioadhesive gel of itraconazole using tamarind gum. Development and evaluation of microemulsion based gel mbgs containing econazole nitrate for nail fungal infection article pdf available in journal of pharmacy research 201254. Optimized emulsion e1 and e4 were used for preparation of emulgel. Pdf microemulsions, which are optically isotropic and thermodynamically stable systems of water, oil, surfactant, andor cosurfactant, have. Microemulsion based gels have emerged as one of the most interesting topical drug delivery system as it has dual control release system i. The bioadhesive potential and antifungal activity of the cmz microemulsionbased gel cmzmbg was determined in comparison to the marketed clotrimazole gel candidv gel by in vitro methods. In microemulsion based gel the reduction of drug particle size to the micron range. However, low viscosity of microemulsion restrains its applicability in pharmaceutical industry. The most widely used class of enzymes in microemulsion based reactions is of lipases 57. Pdf formulation of nimesulide microemulsion based hydrogel. Microemulsions based transdermal drug delivery systems. Antiinflammatory agents are widely used to relieve inflammation caused by various factors. Based on results of previous studies, liquid and gel formulations of m3 and m4 were stored in wellstoppered dark brown glass containers for 6 months at 40c and 75% relative humidity. Quality by design qbd approach for optimization of.
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